Visit the Betway online sportsbook for the latest NFL odds and lines, and Betway’s NFL picks page for picks and predictions throughout the season.
DETROIT LIONS (-3) at Carolina Panthers 20/23
After some wild inconsistency during the early part of the season, the Lions are finally stringing some wins together as they seek their first playoff berth since 2016.
Dan Campbell’s team have racked up six victories in their last seven games, including three in a row heading into Week 16, to find themselves in second place in the NFC North at 7-7.
They currently sit on the outside looking in to the playoff picture, but could easily sneak in to the wild card round with a win or two in their final three games.
A favourable end-of-season schedule first sees them face the 5-9 Panthers, who are coming off a 24-16 loss at home to the Pittsburgh Steelers.
The Panthers have a chance of reaching the playoffs themselves owing to the fact that they are part of the worst division in football, the NFC South, which Tampa Bay currently tops at just 6-8.
The Lions have some serious momentum heading into this one, though, scoring an average of 31 points in their three latest wins over the Jets, Vikings and Jaguars.
Their defence continues to ship a lot of points, but Jared Goff and the offense should put up enough points to win and cover.
CINCINNATI BENGALS (-3.5) at New England Patriots 19/20
The Bengals are finally looking like the team that almost won the Super Bowl last season.
After going 4-4 to start the season, Cincinnati has reeled off six straight wins to climb to the top of the AFC North.
The incredible play of Joe Burrow has been the hallmark of the Bengals’ resurgence, with the quarterback racking up 14 touchdowns in those six straight victories, including two four-touchdown games.
The return of No. 1 receiver Ja’Marr Chase from injury has also been a huge boost for Cincy in recent weeks.
They now face a New England Patriots team who lie just outside the playoff spots at 7-7, but have struggled to build any momentum all season.
The Patriots are also coming off one of the worst losses you’ll see all season against the Las Vegas Raiders. With scores level and time expiring, New England inexplicably decided to lateral the ball around and Kendrick Bourne’s pass was intercepted by Chandler Jones, who took it to the house.
Cincinnati are an NFL-best 11-3 against the spread this season, and should extend that record on Saturday.
TENNESSEE TITANS (-5) vs Houston Texans 20/23
The Titans remain top of the AFC South despite losing their last four games, and will have a great opportunity to arrest the slump against Houston in Week 16.
The Texans are the worst team in the NFL this year, with just one win and one tie to their name after 14 games.
The key to this game will be Derrick Henry and the Titans run game, which has been the backbone of Tennessee’s offense this season.
Henry has exceeded 100 yards in seven games this season, including in his last two, and should find success against the Texans run defence, which ranks bottom in the league.
Houston has given up an average of 167.5 rushing yards per game this season, and Tennessee will look to pound the rock at every opportunity in this one.
Look for Henry to have potentially his biggest game of the season and for the Titans to get a much-needed win here.
SAN FRANCISCO 49ERS (-7.5) vs Washington Commanders 19/20
The 49ers are the most in-form team in the NFL, with seven straight wins securing them the NFC West title with three games to spare.
Their average margin of victory during that run has been 16 points, with their NFL-best defence supported by a well-rounded offense.
Injury troubles at quarterback have threatened to derail San Francisco, but rookie Brock Purdy, Mr. Irrelevant in the 2022 draft, has impressed in three starts.
The Commanders, meanwhile, currently hold onto a playoff spot despite sitting bottom of the NFC East at 7-6-1, owing to poor records elsewhere in the conference.
They are, however, coming off an eight-point loss to the Giants, and face a tough final three games against the 49ers, Browns and Cowboys.
A Washington offense that ranks towards the bottom of the league in points per game is going to struggle against this 49ers defensive unit, and Purdy and the offense should be able to do the rest for San Francisco.