Visit Betway’s NFL picks page for picks and predictions throughout the season.
MINNESOTA VIKINGS (-2.5) vs New Orleans Saints 20/23
The Vikings came from behind to beat the Detroit Lions last week to move to 2-1 for the season, and they currently sit top of the NFC North thanks to a tiebreaking win over the Green Bay Packers in Week 1.
Minnesota running back Dalvin Cook has made a slow start to the season while star wide receiver Justin Jefferson has had a couple of down weeks, but they are simply too talented to struggle for long and this match-up in London looks a good opportunity to bounce back.
The Saints’ defence allowed 22 points against the Carolina Panthers last week, and also gave up 26 against the Atlanta Falcons in Week 1. Neither of those teams have anywhere near as many offensive weapons as the Vikings.
With quarterback Jameis Winston, running back Alvin Kamara and receivers Michael Thomas and Jarvis Landry all banged up, the Saints could be severely limited offensively this week and will struggle to stay within a field goal at the Tottenham Hotspur Stadium.
CLEVELAND BROWNS (-1.5) vs Atlanta Falcons 20/23
The Browns’ 29-17 win over the Pittsburgh Steelers last Thursday pushed them to 2-1 for the season, and they rank sixth in the NFL in points per game despite starting the limited Jacoby Brissett at quarterback.
Brissett has been effective so far, passing for four touchdowns and one interception, while star running back Nick Chubb is averaging 113.7 yards per game on the ground.
The Falcons, meanwhile, are 1-2 after earning their first win of the season against the Seattle Seahawks last week, and have allowed the seventh-most points in the NFL this season.
They’ve been better than expected offensively this season, but the Browns should be able to control possession against Atlanta’s defence on the way to another win.
HOUSTON TEXANS (+4.5) vs Los Angeles Chargers 19/20
The Chargers looked primed for a deep playoff run before the season began, but a 1-2 start and a long list of injuries have made the Super Bowl seem a long way away.
They’re more banged up than just about any team in the league, with quarterback Justin Herbert playing through broken ribs, left tackle Rashawn Slater out for the season, pass rusher Joey Bosa out with a groin injury and receiver Keenan Allen working his way back from a pulled hamstring.
Los Angeles went into last week’s home game against the Jacksonville Jaguars as big favourites but were stunned 38-10, and they now go on the road to face the 0-2-1 Texans.
Houston might be winless, but they earned a tie against the Indianapolis Colts in Week 1 and have been pretty good defensively so far this season. They should be able to keep this game close and cover the spread.
GREEN BAY PACKERS (-9.5) vs New England Patriots 10/11
This is the widest spread of the week, and for good reason. The Patriots are coming off a 37-26 home loss to the Baltimore Ravens, and now travel to the formidable Lambeau Field to face the Packers.
They’ll do so without their starting quarterback, after Mac Jones suffered an ankle injury late in last week’s game. He’ll be replaced by Brian Hoyer, who has lost his last 13 starts, only two of which have come in the last four years.
The Packers opened the season with a 23-7 defeat to the Minnesota Vikings, but they’ve since won two straight against the Chicago Bears and Tampa Bay Buccaneers.
Green Bay’s defence has allowed just 22 points across their last two games, and in a quarterback duel between Hoyer and four-time MVP Aaron Rodgers, this isn’t a hard bet to make.